文献类型：期刊文献

英文题名：Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals

作者：Zhou, Ding[1];Yu, Xueting[1];Zhang, Jian[1];Wang, Wei[1,2];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2016

卷号：14

期号：26

起止页码：6193

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20162802573147);WOS:【SCI-EXPANDED(收录号:WOS:000379483000006)，CCR-EXPANDED(收录号:WOS:000379483000006)】；

基金：We are grateful to the "Thousand Plan" Youth Program, the Fundamental Research Funds for the Central Universities, the National Science Foundation of China (21372073) and the East China University of Science & Technology for financial support.

语种：英文

外文关键词：Positive ions

摘要：A highly enantioselective addition of alcohols to cyclic trifluoromethyl ketimines is developed catalyzed by quinine-thiourea, giving biologically interesting N,O-ketals in up to 99% yield and 96% ee.