文献类型：期刊文献

中文题名：树枝化聚己内酯替莫唑胺微球的制备和表征

英文题名：Preparation and Characterization of Dendronized PCL-PEG-PCL Tri-block Copolymer Temozolomide Drug-loading Microspheres

作者：张艳[1];龚飞荣[1];程树军[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

年份：2012

卷号：41

期号：6

起止页码：75

中文期刊名：塑料

外文期刊名：Plastics

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：复乳法;缓释微球;树枝化聚合物;聚己内酯;替莫唑胺

外文关键词：double emulsion method ; sustained-release microsphere ; dendronized polymer ; polycaprolactone ; temozolomide

摘要：利用哑铃型三嵌段聚己内酯(PCL)-聚乙二醇(PEG)-聚己内酯作为壁材,十二烷基硫酸钠为乳化剂,二氯甲烷为有机溶剂,去离子水为水相介质,通过W/O/W型复乳法制备替莫唑胺(Temozolomide,TMZ)载药微球。制得的载药微球粒径分布窄、平均粒径为2.20～2.42μm,载药量可达到9.01%,体外释放实验的缓释时间达到27 d以上。
Dendronized polycaprolactone-poly（ ethylene glycol）-polycaprolactone temozolomide-loaded microspheres were prepared by water/oil/water （W/O/W） double emulsion method with sodium dodecyl sulfate as emulsifier,dichloromethane as organic solvent, deionezed water as water medium. Microspheres with a range of 2.20 to 3.26 μm in mean diameter with narrow microsphere size distribution were achieved,drug loading could reach 9.01% and release time over 27 d.