文献类型：期刊文献

中文题名：A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

作者：Junwei Chen[1];Na Wang[1];Hongjuan Tong[2];Chao Song[1];Huijuan Ma[1];Yajun Zhang[1];Feng Gao[1];Huan Xu[1];Wei Wang[1,3];Kaiyan Lou[1]

机构：[1]State Key Laboratory of Bioengineering Reactor.Shanghai Key Laboratory of New Drug Design,and Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science & Technology,Shanghai 200237,China;[2]School of Pharmacy,Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China;[3]Department of Pharmacology and Toxicology and BIO5 Institute,University of Arizona,Tucson AZ 85721-0207,United States

年份：2021

卷号：32

期号：12

起止页码：3876

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：supported by the National Natural Science Foundation of China (Nos. 21577037 and 21738002);the State Key Laboratory of Bioreactor Engineering, Shanghai Natural Science Fund (No. 20ZR1414700);Shanghai Sailing Program (No. 19YF1412500);Natural Science Basic Research Program of Shaanxi (No. 2019JQ-924);Key Breeding Program by Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province (No. 2019XT-1-03)。

语种：英文

中文关键词：Fluorescent probe;Circular dichroism;Heavy metal ions;Dual-modality;Detoxification;Cascade reaction;Divergent responses

摘要：Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.