文献类型：期刊文献

英文题名：Convenient access to L-3,4,5-trioxygenated phenylalanine compounds from L-tyrosine

作者：Zhou, Shengfeng[1,2];Zhou, Chen[1,2];Lu, Qian[1,2];Liu, Xintong[1,2];Yuan, Jie[1,2];Yu, Xinhong[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioengn Reactors, Shanghai Key Lab New Drug Design, Engn Res Ctr Pharmaceut Proc Chem,Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：76

期号：24

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000537423800002)，CCR-EXPANDED(收录号:WOS:000537423800002)】；

基金：We are grateful to financial support from National Natural Science Foundation of China (No.21476078) and Science and Technology Commission of Shanghai Municipality (No. 12431900902).

语种：英文

外文关键词：Trioxygenated phenylalanine; L-tyrosine; Bishydroxylation; Trabectedin

摘要：A convenient and efficient synthesis of L-3,4,5-trioxygenated phenylalanine derivatives from L-tyrosine was developed. Dibromo phenylalanine is converted easily to bis-phenol via copper-catalyzed hydroxylation. The synthetic potential of this methodology has been demonstrated by efficient synthesis of L-3,4,5-trimethoxyphenylalanine methyl ester and one key intermediate of Trabectedin. (C) 2020 Published by Elsevier Ltd.