文献类型：期刊文献

英文题名：Fluorescence imaging of metal ions implicated in diseases

作者：Qian, Xuhong[1];Xu, Zhaochao[2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem CAS, Dalian 116023, Peoples R China

年份：2015

卷号：44

期号：14

起止页码：4487

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000357691200002)】；

基金：X.Q. thanks the National Natural Science Foundation of China (21236002). Z.X. thanks financial support from the National Natural Science Foundation of China (21276251, 21422606), Ministry of Human Resources and Social Security of PRC, the 100 talents program funded by Chinese Academy of Sciences.

语种：英文

摘要：Metal ions play an important role in various biological processes, their abnormal homeostasis in cells is related to many diseases, such as neurodegenerative disease, cancer and diabetes. Fluorescent imaging offers a unique route to detect metal ions in cells via a contactless and damage-free way with high spatial and temporal fidelity. Consequently, it represents a promising method to advance the understanding of physiological and pathological functions of metal ions in cell biology. In this highlight article, we will discuss recent advances in fluorescent imaging of metal ions by small-molecule sensors for understanding the role of metals in related diseases. We will also discuss challenges and opportunities for the design of small-molecule sensors for fluorescent detection of cellular metal ions as a potential method for disease diagnosis.