文献类型：期刊文献

英文题名：New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

作者：Hu, Jiansen[1,2];Li, Zheng[1,2];Gao, Jieyu[1,3];He, Hongtao[1,2];Dai, Huanqin[1];Xia, Xuekui[4];Liu, Cuihua[1];Zhang, Lixin[5];Song, Fuhang[1]

机构：[1]Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China;[2]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[3]Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China;[4]Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Key Biosensor Lab Shandong Provinde, Jinan 250013, Shandong, Peoples R China;[5]East China Univ Sci Technol, State Key Lab Bioreactor Engn, Shanghai 200031, Peoples R China

年份：2019

卷号：17

期号：5

外文期刊名：MARINE DRUGS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000470964600015)】；

基金：This work was supported by grants from the National Key R&D Program of China (2018YFC0311002, 2017YFD0201203, 2017YFC1601300, 2017YFE0108200), the National Natural Science Foundation of China (31600136, 31430002, 31720103901), the Fundamental Research Funds for the Central PublicWelfare Research Institutes (Z0547). Taishan Scholarship for Lixin Zhang and the Fundamental Research Funds for the Central Universities 22221818014.

语种：英文

外文关键词：marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial

摘要：Six new diketopiperazines, (+/-)-7,8-epoxy-brevianamide Q ((+/-)-1), (+/-)-8-hydroxy-brevianamide R ((+/-)-2), and (+/-)-8-epihydroxy-brevianamide R ((+/-)-3), together with four known compounds, (+/-)-brevianamide R ((+/-)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guerin. Compounds 1-4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.