文献类型：期刊文献

英文题名：Synthesis and effects of new caffeic acid derivatives on nitric oxide production in lipopolysaccharide- induced RAW 264.7 macrophages

作者：Zhang, Jie[1];Xu, Liu-Xin[1];Xu, Xu-Sheng[1];Li, Bo-Wei[1];Wang, Rui[1];Fu, Jian-Jun[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2014

卷号：7

期号：4

起止页码：1022

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000336740600029)】；

基金：The work was supported by the Natural Science Foundation of Shanghai, China (11ZR1446300), the Shanghai Committee of Science and Technology, China (12431900901), the Fundamental Research Funds for the Central Universities of China and in part by National Science and Technology Major Projects of China for "Major New Drugs Innovation and Development" (2012ZX09J12202-004).

语种：英文

外文关键词：Caffeic acid; structure modification; condensation; nitric oxide; anti-inflammatory

摘要：In this study, 20 new derivatives of caffeic acid esters were synthesized and their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages were determined. Compounds 3l, 3r, 3s and 3t were found to decrease nitrite levels in a dose-dependent manner in LPS-induced cells and showed potent inhibitory activities against the NO production in RAW264.7 macrophages with IC50 values of 7.4, 5.9, 3.3 and 2.2 mu M, respectively. They could be selected as compromising compounds for the later pharmacological study.