文献类型：期刊文献

英文题名：Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives

作者：Xue, Chenwei[1,2];Han, Jianwei[1,2,3];Zhao, Min[1,2];Wang, Limin[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2019

卷号：21

期号：12

起止页码：4402

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000473116000002)】；

基金：The work was supported by the National Key Research and Development Program (2016YFA0200302), National Nature Science Foundation of China (NSFC 21772039, 21472213), as well as by Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant, the Fundamental Research Funds for the Central Universities, Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03) and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

摘要：By using diaryliodonium salts, a novel approach of a palladium-catalyzed cascade of diarylation/intramolecular dehydrogenative coupling reaction has been developed in the synthesis of phenanthro-imidazopyridine fused heteropolycycles. The method can tolerate various substrates, and the target products were rapidly constructed in one pot. Furthermore, studies of the detailed reaction mechanism provide an insight into the C-H functionalization of 2-aryl-imidazopyridine derivatives and the C-C bond formations in the presence of palladium catalyst.