文献类型：期刊文献

英文题名：Biodegradable Nanobowls with Controlled Dents

作者：Jiang, Jinhui[1,2];Sun, Min[2];Gu, Qianxi[2];Liu, Shangning[2];Sun, Hui[3];Fan, Zhen[2];Zhu, Yunqing[2];Du, Jianzhong[1,2,4]

机构：[1]Tongji Univ, Shanghai Peoples Hosp 4, Anesthesiol & Perioperat Med Translat Res Inst Bra, Clin Res Ctr,Dept Gynaecol & Obstetr,Shanghai Key, Shanghai 200434, Peoples R China;[2]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[3]Ningxia Univ, Sch Chem & Chem Engn, State Key Lab High Efficiency Coal Utilizat & Gree, Yinchuan 750021, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2024

卷号：14

期号：1

起止页码：35

外文期刊名：ACS MACRO LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001380420200001)】；

基金：This project is supported by the National Natural Science Foundation of China (21925505, 51903190, 51803152, 52222306, 22075212, 22301152 and 22175131), International Scientific Collaboration Fund of Science and Technology Commission of Shanghai Municipality (23520710900), the National Key R&D Program of China (2022YFC2402901-4), Tongcheng Youth Research and Development Fund (CPCIF-RA-0104), and Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28). J.D. is the recipient of the National Science Fund for Distinguished Young Scholars.

语种：英文

摘要：Nanobowls show promising potential in biomedical applications, such as bioimaging, cargo delivery, and disease theranostics, due to their unique concave structure and interior cavities. However, the lack of biodegradable nanobowls with manipulable size (especially the dent size) still exists as an obstacle for their in-depth exploration and application in biomedical fields. Herein, polypeptide-based nanobowls are successfully obtained by the self-assembly of a graft polypeptide [named TPE-P(GAAzo21-stat-GA29)] via a solvent-switch method. Through the synergistic effect between the hydrogen bonding and pi-pi stacking interactions, the size of nanobowls and the corresponding dents can be facilely controlled by altering either the initial polypeptide concentration or the cosolvents in self-assembly. Furthermore, such polypeptide-based nanobowls are demonstrated to be biocompatible and biodegradable in vitro, which may promote the development of biomedical nanobowls in the future.