文献类型：期刊文献

英文题名：Enantioselective Vinylogous Michael/Cyclization Cascade Reaction of Acyclic β,γ-Unsaturated Amides with Isatylidene Malononitriles: Asymmetric Construction of Spirocyclic Oxindoles

作者：Li, Tian-Ze[1,2];Xie, Jin[1,2];Jiang, Yu[1,2];Sha, Feng[1,2];Wu, Xin-Yan[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：357

期号：16-17

起止页码：3507

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000368342400018)，CCR-EXPANDED(收录号:WOS:000368342400018)】；

基金：We are grateful for the financial support from the National Natural Science Foundation of China (21102043), the Science and Technology Commission of Shanghai Municipality (15ZR1409200), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：cascade reaction; cyclization; enantioselective organocatalysis; spirocyclic oxindoles: vinylogous Michael reaction

摘要：The first direct and enantioselective vinylogous Michael/cyclization cascade reaction between acyclic beta,gamma-unsaturated amides and isatvlidene malononitriles has been developed. Optically active spirocyclic oxindoles have been obtained in good-to-excellent yields (84-96%) and enantioselectivity (79-97% ee) in the presence of 2 mol% (DHQD)(2)PYR [2,5-dipheny1-4,6-bis(9-O-dihydroquinyl)pyrimidine.]