文献类型：期刊文献

英文题名：Synthesis and Characterization of D--Tocopheryl Polyethylene Glycol 1000 Succinate-Block-Poly (ε-caprolactone) Copolymer Used as Carriers for Microparticles

作者：Ren, Fuzheng[1];Jing, Qiufang[1];Cui, Jingbin[1];Shen, Yongjia[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China

年份：2009

卷号：30

期号：8

起止页码：1129

外文期刊名：JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

收录：;EI(收录号：20094712485458);WOS:【SCI-EXPANDED(收录号:WOS:000268707100002)】；

基金：The authors would like to thank the research fund for the young teachers by Shanghai Municipal Education Commission and East China University of Science and Technology.

语种：英文

外文关键词：Copolymer; D--tocopheryl polyethylene glycol 1000 succinate; microparticle; poly (epsilon-caprolactone)

摘要：A novel copolymer, D--tocopheryl polyethylene glycol 1000 succinate-block-Poly (epsilon-caprolactone) (TPGS-block-PCL), was synthesized and characterized by 1H-NMR and FTIR. The molecular weight was determined by gel permeation chromatography. TPGS-block-PCL can be used to prepare microparticles for drug delivery system by a modified solvent extraction/evaporation method without extra emulsifier. The risperidone-loaded microparticles were characterized by laser light scattering for particle size and by scanning electron microscopy (SEM) for surface morphology. The drug encapsulation efficiency and the in vitro drug release profiles were measured. A significantly higher drug release rate was observed for microparticles with TPGS-block-PCL copolymer than PCL.