文献类型：期刊文献

英文题名：Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer

作者：Tong, Pei-Hong[2,3];Yang, Jing-Jie[2,3];Zhou, Yu-Fan[2,3];Tang, Yi-Fan[9];Tang, Meng-Tian[2,3];Zang, Yi[5];Pan, Yu-Fei[1];Dong, Li-Wei[1];Tan, Ye-Xiong[1];Nam, Ki Taek[6];Hu, Xi-Le[2,3];Huang, He[4];Li, Jia[4];Wang, Hong-Yang[1];James, Tony D.[7,10];Yoon, Juyoung[8];He, Xiao-Peng[1,2,3]

机构：[1]Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem,Key Lab Adv, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem,Joint Int R, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China;[5]Lingang Lab, Shanghai 201203, Peoples R China;[6]Yonsei Univ, Coll Med, Dept Biomed Sci, Brain Korea 21 PLUS Project Med Sci, Seoul 03760, South Korea;[7]Univ Bath, Dept Chem, Bath BA2 7AY, England;[8]Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea;[9]Xian Jiaotong Liverpool Univ, Acad Pharm, Suzhou 215123, Peoples R China;[10]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

年份：2025

卷号：526

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001383727900001)】；

基金：The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 92253306, 82130099, 22108077 and 22477030) , the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03) , the International Cooperation Program of Shanghai Science and Technology (No.23490711600) , the Fundamental Research Funds for the Central Universities (222201717003) , the Programme of Introducing Talents of Discipline to Universities (B16017) , the Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Drug Research (SKLDR-2023-KF-10) and Ministry of Education Key Laboratory on signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University) (Grant. 2023-MEKLLC-MS/ZD-00*) . J.Y. and K.T.N. thank for financial support. The Nano & Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT (RS-2024-00407093, K.T.N. and J.Y.) . J.Y. thanks to the support by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. 2022M3E5F3080873, J.Y.) . T.D.J. wishes to thank the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support. The Research Center of Analysis and Test of East China University of Science and Technology was gratefully acknowledged for assistance in analytical experiments.

语种：英文

外文关键词：Metal-organic frameworks (MOFs); Phototherapy; Photodynamic therapy; Photothermal therapy; Synergistic therapy; Cancer

摘要：Phototherapy is a form of light-mediated therapy, which includes photodynamic therapy (PDT) photothermal therapy (PTT), and the recently emerging photoimmunotherapy (PIT). PTT, PDT, PIT and their combinations with conventional chemotherapeutics have been used extensively to treat cancer due to their outstanding therapeutic efficacy, are non-invasive, mitigate side effects, and display spatial selectivity for a target organ. In addition to the many anticancer phototherapeutic agents developed, metal-organic frameworks (MOFs) are a new generation of promising light-responsive materials owing to their readily tunable chemical structures through simple coordination chemistry as well as their morphological diversity. When properly designed, MOFs can also serve as photodynamic and/or photothermal agents themselves whilst being a carrier to deliver chemoand macromolecular therapeutic agents owing to their highly tunable porosity. This review highlights recent research progresses made in the development of MOFs-based materials for phototherapy and synergistic phototherapy, as well as discussing any remaining challenges.