文献类型：期刊文献

英文题名：Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation

作者：Gu, Jinlou[1];Huang, Kai[1];Zhu, Xiangyang[1];Li, Yongsheng[1];Wei, Jie[1];Zhao, Wenru[1];Liu, Changsheng[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2013

卷号：407

起止页码：236

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20133416640955);WOS:【SCI-EXPANDED(收录号:WOS:000323470300031)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2012CB933602), Natural Science Foundation of China (51072053, 51132009, 21001043), the Fundamental Research Funds for the Central Universities (WD 1114004), the Innovation Program of Shanghai Municipal Education Commission (13zz040) and the Nano-Special Foundation for Shanghai Committee of Science and Technology (12nm0502600).

语种：英文

外文关键词：Mesoporous silica; Nanoparticles; Tunable pore size; Protein encapsulation; Drug delivery

摘要：Despite their great potentials as biomacromolecues delivery vehicles, there are few, if any, reports on mesoporous silica nanoparticles (MSNs) simultaneously integrated with the merits of large pore size, small particle diameters and well-ordered mesostructure. Here, we designed a facile strategy for the synthesis of monodispersed MSNs using cationic surfactants (CSs) as templating agents, neutral amine of N,N-dimethylhexadecylamine (DMHA) as a pore size mediator and tri-block copolymer of F127 (EO106PO70EO106) as a particle growth inhibitor/dispersant. The obtained colloidal nanoparticles exhibited a highly ordered mesostructure and tunable pore diameter up to 4.6 nm (BJH) and monodispersed particle sizes less than 150 nm. A model protein of cytochrome c (CytC) was exemplified to be accommodated in the resultant MSNs and its loading amount was correlated with their pore size. The efficient cancer cellular uptake of the large-pore MSNs prefigured their potentials as intracellular delivery vehicles for membrane-impermeable proteins. (C) 2013 Elsevier Inc. All rights reserved.