文献类型：期刊文献

英文题名：Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs

作者：Zhang, Jue[1];Cai, Liang[1];Tang, Liangchen[1];Zhang, Xiaochen[2];Yang, Lili[3];Zheng, Kai[4];He, Axiang[3];Boccaccini, Aldo R.[4];Wei, Jie[1];Zhao, Jun[2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med,Dept Orthodont, Shanghai Res Inst Stomatol,Shanghai Key Lab Stoma, Shanghai 200011, Peoples R China;[3]Second Mil Med Univ, Changzheng Hosp, Dept Orthoped Surg, Shanghai 200003, Peoples R China;[4]Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany

年份：2018

卷号：170

起止页码：563

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20182705407417);WOS:【SCI-EXPANDED(收录号:WOS:000445989400066)】；

基金：The grants were from the National Natural Science Foundation of China (81771990, 81572194 and 81271705), the National key research and development program (2016YFC1102100), the Major International Joint Research Project between China and Korea (81461148033) and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：Lithium; Mesoporous silica nanospheres; Proliferation; Differentiation; Genes expression

摘要：Lithium (Li) doped mesoporous silica nanospheres (LMSNs) were synthesized by incorporation of 5 wt% Li into mesoporous silica nanospheres (MSNs) using sol-gel method. The results showed that LMSNs with a mean size of approximate 300 nm exhibited uniform and highly dispersed spherical morphology, which was similar to the morphology of MSNs. Moreover, the degradability of MSNs was significantly increased after the incorporation of Li, and LMSNs could release both silicon (Si) and Li ions in a sustained manner. Due to the release of Li ions, LMSNs showed higher stimulatory effects on the attachment and proliferation of bone marrow mesenchymal stem cells (BMSCs) than MSNs. In addition, LMSNs could also enhance the ALP activity of BMSCs as well as improving osteogenesis related genes (OPN, ALP, Runx2 and OCN) expression of BMSCs. In summary, LMSNs have shown the capability of being a carrier of biologically active ions, which exhibit great potential in bone repair/regeneration applications.