文献类型：期刊文献

英文题名：Direct assembly of anticancer drugs to form Laponite-based nanocomplexes for therapeutic co-delivery

作者：Zheng, Ling[1,2];Zhou, Bingjie[1,2];Qiu, Xiaofeng[1,2];Xu, Xin[1,2];Li, Gang[3];Lee, Wayne Y. W.[3];Jiang, Jia[4];Li, Yulin[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Fac Med, Hong Kong, Peoples R China;[4]Shanghai 6th Peoples Hosp, Dept Sports Med, Shanghai 200237, Peoples R China

年份：2019

卷号：99

起止页码：1407

外文期刊名：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

收录：;EI(收录号：20190906564904);WOS:【SCI-EXPANDED(收录号:WOS:000463121200134)】；

基金：This research was supported by the National Key Research and Development Program of China (2017YFB0309300), the National Natural Science Foundation of China (81772317) and the Key Program of National Natural Science Foundation of China (31330028). The funding grant from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) was also acknowledged.

语种：英文

外文关键词：Laponite; Doxorubicin; Methotrexate; Sequential delivery; Anticancer

摘要：The multidrug resistance of tumor cells has been creating a high requirement on development of nanocarriers for administration of different drugs, among which their drug loading capacity and controllable release properties are the key factors to overcome tumor drug resistance. This study aims to use a kind of bioactive 2D nanoplatelets (25 nm in diameter and 0.92 nm in thickness) to load different anticancer drugs (doxorubicin and methotrexate) via a step-by-step assembly, where variation of each drug amount can be used for adjustment of the sizes of the resulting nanocomplexes. The dual-drug loaded nanosystems allow for a sequential release of the loaded drugs. Furthermore, drug release rate can be accelerated under both acidic pathological triggers of tumors and/or by heating treatment, resulting in a synergistic anticancer bioactivity. The drug-mediated formation of nanocarriers may enlighten a design of novel nanoplatform for co-delivery of therapeutic agents, beyond anticancer drugs, in a combinative way for drug delivery applications.