文献类型：期刊文献

英文题名：Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

作者：Zou, Jiafeng[1];Yuan, Zeting[1];Chen, Xiaojie[2];Chen, You[1];Yao, Min[1];Chen, Yang[1];Li, Xiang[1];Chen, Yi[1];Ding, Wenxing[1];Xia, Chuanhe[1];Zhao, Yuzheng[1,4,5,6,7];Gao, Feng[1,3,4,5]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China;[2]Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pro, Hangzhou 310053, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ctr, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[6]Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Shanghai 200031, Peoples R China;[7]Chinese Acad Med Sci, Res Unit New Tech Live Cell Metab Imaging, Beijing 100050, Peoples R China

年份：2024

卷号：19

期号：1

外文期刊名：ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001171593600001)】；

基金：This work was supported by National Key Research and Development Program of China (contract No.2019YFA0904800) , National Nature Science Foundation of China (32030065 , 31722033 , 92049304 to Y.Z.) , Shanghai Sailing Program (contract No. 21YF1410300) , Science and Technology Commission of Shanghai Municipality (contract No.10DZ2220500) and The Shanghai Committee of Science and Technology (grant No.11DZ2260600) . Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Y.Z.) , Research Unit of New Techniques for Live -cell Metabolic Imaging (Chinese Academy of Medical Sciences , 2019-I2M-5- 013 to Y.Z.) , the State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Hydrogen sulfide; Disease mechanisms; Removal of hydrogen sulfide; Responsive nanoplatforms; Challenges; Biomedical applications

摘要：Hydrogen sulfide (H2S) is a toxic, essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter. These studies have mainly focused on the production and pharmacological side effects caused by H2S. Therefore, effective strategies to remove H2S has become a key research topic. Furthermore, the development of novel nanoplatforms has provided new tools for the targeted removal of H2S. This paper was performed to review the association between H2S and disease, related H2S inhibitory drugs, as well as H2S responsive nanoplatforms (HRNs). This review first analyzed the role of H2S in multiple tissues and conditions. Second, common drugs used to eliminate H2S, as well as their potential for combination with anticancer agents, were summarized. Not only the existing studies on HRNs, but also the inhibition H2S combined with different therapeutic methods were both sorted out in this review. Furthermore, this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail. Finally, potential challenges of HRNs were proposed. This study demonstrates the excellent potential of HRNs for biomedical applications. (c) 2023 Shenyang Pharmaceutical University. Published by Elsevier B.V. This is an open access article under the CC BY -NC -ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )