文献类型：期刊文献

英文题名：Catalytic Asymmetric Formal Aza-Diels-Alder Reactions of α,β-Unsaturated Ketones and 3H-Indoles

作者：Hu, Haoxiang[1];Meng, Chunna[1];Dong, Yun[1];Li, Xin[1];Ye, Jinxing[1,2]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：5

期号：6

起止页码：3700

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20152400930387);WOS:【SCI-EXPANDED(收录号:WOS:000355964300057)】；

基金：This work was supported by National Natural Science Foundation of China (21272068), Innovation Program of Shanghai Municipal Education Commission (11ZZ56), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：asymmetric catalysis; amine; aza-Diels-Alder; cycloaddition; piperidinone; bifunctional catalyst

摘要：Asymmetric formal aza-Diels-Alder reactions with alpha,beta-unsaturated ketones and 3H-indoles with disubstituted groups on the C3 position catalyzed by primary amine-thiourea bifunctional catalyst have been developed. The reactions produced chiral hexahydropyrido-[1,2-a]indole-2-ones in high yields with excellent diastereo- and enantioselectivities.