文献类型：期刊文献

英文题名：Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy

作者：Hua, Yujie[1,2];Xia, Huitang[1,3];Jia, Litao[2,3];Zhao, Jinzhong[4];Zhao, Dandan[2,3];Yan, Xiaoyu[4];Zhang, Yiqing[5,6];Tang, Shengjian[3];Zhou, Guangdong[1,2,3];Zhu, Linyong[5,6,7];Lin, Qiuning[7]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Tissue Engn, Dept Plast & Reconstruct Surg,Shanghai Peoples Ho, Shanghai, Peoples R China;[2]Natl Tissue Engn Ctr China, Shanghai, Peoples R China;[3]Weifang Med Univ, Res Inst Plast Surg, Weifang, Shandong, Peoples R China;[4]Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Sports Med, Shanghai, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[6]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[7]Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China

年份：2021

卷号：7

期号：35

外文期刊名：SCIENCE ADVANCES

收录：;EI(收录号：20213510829570);WOS:【SCI-EXPANDED(收录号:WOS:000689735500007)】；

基金：This work was financially supported by National Key Research and Development Program of China (2019YFA0110500 and 2017YFC1103900), the National Nature Science Foundation of China (22022506 and 21774030), Shanghai Municipal Science and Technology Major Project (grant no.2018SHZDZX03), the Program of Shanghai Technology Research Leader (18XD1421500), and the China Postdoctoral Science Foundation (2020M681332).

语种：英文

外文关键词：Adhesives - Gelation - Scaffolds (biology) - Cartilage - Repair

摘要：A hydrogel scaffold for direct tissue-engineering application in water-irrigated, arthroscopic cartilage repair, is badly needed. However, such hydrogels must cure quickly under water, bind strongly and permanently to the surrounding tissue, and maintain sufficient mechanical strength to withstand the hydraulic pressure of arthroscopic irrigation (similar to 10 kilopascal). To address these challenges, we report a versatile hybrid photocrosslinkable (HPC) hydrogel fabricated though a combination of photoinitiated radical polymerization and photoinduced imine cross-linking. The ultrafast gelation, high mechanical strength, and strong adhesion to native tissue enable the direct use of these hydrogels in irrigated arthroscopic treatments. We demonstrate, through in vivo articular cartilage defect repair in the weight-bearing regions of swine models, that the HPC hydrogel can serve as an arthroscopic autologous chondrocyte implantation scaffold for long-term cartilage regeneration, integration, and reconstruction of articular function.