文献类型：期刊文献

中文题名：溶液喷纺法制备聚乳酸/锂藻土复合纳米纤维膜及其性能

英文题名：Fabrication and Properties of PLLA/Laponite Composite Nanofiber Membranes via Airbrushing

作者：秋晓锋[1];罗炜[1];屈雪[1];李玉林[1];刘昌胜[1]

机构：[1]华东理工大学材料科学与工程学院教育部医用生物材料工程研究中心

年份：2019

卷号：32

期号：4

起止页码：454

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：国家自然科学基金(81772317)

语种：中文

中文关键词：溶液喷纺法;纳米纤维膜;聚乳酸;锂藻土;降解性;生物相容性

外文关键词：airbrushing;nanofiber membrane;polylactide;Laponite;degradability;biocompatibility

摘要：为改善聚左旋乳酸(PLLA)的亲水性和生物活性,采用溶液喷纺法将具有良好亲水性和生物活性的锂藻土(LAP)复合到PLLA纳米纺丝膜中。采用扫描电镜(SEM)、傅里叶红外光谱(FT-IR)、万能试验机、接触角测量仪对纤维膜的形貌、化学结构、力学性能和亲水性进行了表征,并研究了纤维膜的降解性能和细胞相容性。结果表明,适量LAP可在PLLA纳米纤维中均匀分布,所得PLLA/LAP杂化纳米纤维直径为200~300 nm。LAP的引入有助于改进PLLA的亲水性,并提高其力学性能,同时可在一定程度上调节PLLA的降解速率。体外生物学评估表明,LAP的引入能提高纳米纺丝膜的细胞增殖效应。
In order to enhance the hydrophilicity and bioactivity of poly(L-lactic acid)(PLLA),Laponite(LAP)with good hydrophilicity and nanodisked structure was integrated into PLLA nanofiber membranes using an airbrushing technique.The morphology,chemical structure,mechanical properties and hydrophilicity of the nanofiber membranes were characterized by scanning electron microscopy(SEM),Fourier transform infrared analysis(FT-IR),universal testing machine and contact angle measuring instrument.Their biodegradability and cytocompatability were also investigated.It was found that the airbrushing technique allowed for homogeneous introduction of LAP in PLLA matrix to form hybrid nanofiber membranes containing fibers with diameters of 200-300 nm.LAP modification was beneficial to the improvement of the hydrophilicity of the native PLLA nanofiber membranes(with water contact angle changing from 120°for PLLA to 100°for the modified one).Compared to the native PLLA nanofiber membranes,composite nanofiber membranes with 3%LAP(the mass ratio of LAP to PLLA was 3%)presented a 2.5-fold enhancement in tensile strength and a 4-fold increase in Young's modulus.The LAP-modified systems displayed accelerated degradation rate probably due to their hydrophilicity.In vitro biological evaluation displayed that the composite nanofiber membranes could promote the proliferation of C2C12 cells,indicating their potential as a kind of new biomaterial for tissue regeneration.