文献类型：期刊文献

英文题名：A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt

作者：Yu, Feng[1];Jin, Zhichao[1];Huang, Huicai[1];Ye, Tingting[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2010

卷号：8

期号：20

起止页码：4767

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20104113284802);WOS:【SCI-EXPANDED(收录号:WOS:000282315900037)，CCR-EXPANDED(收录号:WOS:000282315900037)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (20902018), Shanghai Pujiang Program (08PJ1403300), the Fundamental Research Funds for the Central Universities and 111 Project (B07023),

语种：英文

外文关键词：Catalysis - Addition reactions - Thioureas

摘要：The first highly efficient Michael addition of challenging alpha,alpha-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon centers in high yields (up to 99%) with excellent enantioselectivities (91-99%).