文献类型：期刊文献

英文题名：Dearomatization of Indoles via a Phenol-Directed Vanadium-Catalyzed Asymmetric Epoxidation and Ring-Opening Cascade

作者：Han, Long[1,2];Zhang, Wei[1];Shi, Xiao-Xin[2];You, Shu-Li[1,2]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：357

期号：14-15

起止页码：3064

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000363507400008)】；

基金：We thank the National Basic Research Program of China (973 Program 2015CB856600) and National Natural Science Foundation of China (21272252, 21332009, 21421091) for generous financial support.

语种：英文

外文关键词：asymmetric catalysis; dearomatization; epoxidation; indoles; vanadium

摘要：An enantioselective dearomatization of indole derivatives was realized by the complexes derived from the vanadium complex VO(acac)(2) and C-2-symmetric bis-hydroxamic acid (BHA) ligands. The reaction proceeded via asymmetric epoxidation and ring-opening by the linked phenol cascade, affording 5a, 6,10b, 11-tetrahydrochromeno[2,3-b]-indol-10b-ol derivatives in up to 83% yield and 98% ee under mild reaction conditions.