文献类型：期刊文献

英文题名：Dimefluthrin induces female-specific reproductive toxicity in zebrafish (Danio rerio) after long-term exposure to low concentrations

作者：Wang, Wei-Guo[1,2]; Li, Rui-Rui[1,2]; Yang, Ming-Jun[3]; Hu, Jing-Ying[3]; Xu, Wen-Ping[1,2]; Tao, Li-Ming[1,2]; Zhang, Yang[1,2]

机构：[1] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; [2] State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China; [3] NHC Key Lab of Reproduction Regulation, Shanghai Engineer Research Center of Reproduction Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China

年份：2026

外文期刊名：SSRN

收录：EI(收录号：20260124580)

语种：英文

外文关键词：Endocrine disrupters - Endocrinology - Insecticides - Physiology - Public health - Toxicity

摘要：The extensive use of household insecticides has been potentially linked to an increase in human health issues such as respiratory irritation, neurotoxicity, and endocrine disruption, raising significant concerns about their potential risks. Dimefluthrin demonstrates significant insecticidal efficacy against public health pests such as mosquitoes, flies, cockroaches, and bed bugs, and is widely applied in the field of public health. Long-term exposure of zebrafish to low doses of dimefluthrin resulted in apparent reproductive toxicity in adults, including abnormal condition factors, gonadal structural damage, abnormal mating behavior, and reduced embryo quality (spawning amount, fertilization rate, hatching rate, and survival rate). Further investigation into the effects of dimefluthrin on the endocrine system of zebrafish offspring revealed that long-term exposure caused multiple endocrine-disrupting effects in the HPT/HPA/HPG axis. Dysfunction of the HPT axis was associated with dysregulated T4 metabolism; impairment of the HPA axis was related to abnormal secretion of ACTH and COR; and reproductive dysfunction of the HPG axis was linked to abnormal secretion of E2 and T, as well as disruptions in the E2 synthesis pathway. Additionally, dimefluthrin exhibited more pronounced reproductive toxicity and transgenerational toxicity in female zebrafish. ? 2026, The Authors. All rights reserved.