文献类型：期刊文献

英文题名：Carbonyl-Bridged Trifluoromethyl Pyridine Derivatives for Pest Control and Mechanistic Investigations

作者：Sheng, Zhubo[1]; Deng, Jie[1]; Yuan, Qinglong[1]; Fu, Wen[1,5]; Xu, Zhiping[1]; Li, Xiaoyan[6]; Li, Zhong[1,2]; Shao, Xusheng[1,2,3,4]

机构：[1] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology [ECUST], Shanghai, 200237, China; [2] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; [4] Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; [5] National Key Laboratory of Green Pesticide, Guizhou University, Guizhou, Guiyang, 550025, China; [6] College of Humanities and Economic Management, Yantai Institute of China Agricultural University, Shandong, Yantai, 264670, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250172656)

语种：英文

外文关键词：Synthesis (chemical)

摘要：Trifluoromethyl pyridine (TFMP) motif is commonly discovered in structures of active pharmaceuticals. Flonicamid, characterized by the TFMP moiety, is well known as a prodrug in the knockdown of pests. The azobenzene-modified TFMP derivatives have been previously reported with excellent insecticidal activities. Herein, twenty-one TFMP derivatives were designed by the introduction of carbonyl-bridged aryl groups and synthesized via a one-step synthesis using Flonicamid as the starting material. The structure-activity relationships of these compounds were well analyzed and discussed. A molecular docking study and calcium ion concentration analysis indicated that compound FC13 could have interacted with the nicotinamidase enzyme, which further influenced the Ca2+ influx. ? 2025, The Authors. All rights reserved.