文献类型：期刊文献

英文题名：Dynamic solution-out crystallization process of erythromycin

作者：Chen, Kui; Zhu, Jia-Wen; Ji, Li-Jun; Wu, Bin

机构：[1] Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, China

年份：2006

卷号：32

期号：8

起止页码：897

外文期刊名：Huadong Ligong Daxue Xuebao /Journal of East China University of Science and Technology

收录：EI(收录号：20064110166019)

语种：英文

摘要：The crystallization process of erythromycin critically influences the quality of the final product. The solution-out crystallization process of erythromycin was studied when erythromycin lactate was employed as initial material. The crystallization temperature, the quantity, the way and the flow rate of water introduced into erythromycin acetone solution were analyzed for their effects on the crystal structure, purity and yield of crystallization. The operation temperature at 45 °C to 50 °C is more favorable to crystallization, while the formation of a large rectangle crystal is observed. A stable, low rate of introduction of water is beneficial to controlling the super solubility, and therefore favors the formation of larger and purer crystals. High temperature and high stirring intensity to initiate crystallization followed by low temperature and low stirring intensity to extend the growth of the crystal can favor the formation of uniform, rectangle-shaped crystals with apparently larger crystal volume, even size distribution. The product with high titre is thus obtained.