文献类型：期刊文献

英文题名：Multifunctional Superparamagnetic Fe3O4@SiO2 Core/Shell Nanoparticles: Design and Application for Cell Imaging

作者：Zhao, Xueling[1,2];Zhao, Hongli[1,2];Yuan, Huihui[1,2];Lan, Minbo[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2014

卷号：10

期号：2

起止页码：262

外文期刊名：JOURNAL OF BIOMEDICAL NANOTECHNOLOGY

收录：;EI(收录号：20140617274464);WOS:【SCI-EXPANDED(收录号:WOS:000327496500007)】；

基金：This work was supported by the National Natural Science Foundation of China (NSFC, Contract No. 21074033) and the Science and Technology Commission of Shanghai Municipality (STCSM, Contract No. 12nm0501100).

语种：英文

外文关键词：Magnetic Nanoparticles; Core/Shell; Multifunctional; Biocompatible; Cell Imaging

摘要：Highly biocompatible sub-50-nm monodisperse superparamagnetic Fe3O4@SiO2 core/shell nanoparticles with luminescent silica shells were synthesized by a w/o-microemulsion technique. And then these nanoparticles were coated with the covalently bonded biocompatible polymer poly(ethylene glycol) (PEG) and modified with the biological cancer targeting ligand folic acid (FA). After characterized by means of powder X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transformed infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), UV-vis, fluorescence spectroscopy and confocal laser scanning microscopy (CLSM), we confirmed that Fe3O4@SiO2 (FITC)-PEG-FA nanocomposites (SMNPs-FA) could be efficiently taken up by HeLa cancer cells and KB cells which are of over-expression of folate receptors. The multifunctional nanomaterials exhibited superparamagnetic, monodisperse, highly biocompatible, intensively fluorescent and capable of recognizing and binding cells that overexpress folate receptors, which would be useful for targeting cell imaging and provide an excellent platform for further development of an efficient cancer therapy.