文献类型：期刊文献

英文题名：Fluorescence and photoacoustic (FL/PA) dual-modal probe: Responsive to reactive oxygen species (ROS) for atherosclerotic plaque imaging

作者：Yu, Qianqian[1,2];Duan, Yi[3];Liu, Nian[4];Zhu, Zhirong[1,2];Sun, Ying[3];Yang, Haojian[1,2];Shi, Yiqi[1,2];Li, Xiangyu[1,2];Zhu, Wei-Hong[1,2];Wang, Lixin[5];Wang, Qi[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Sch Med, Shanghai 200030, Peoples R China;[4]Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Nucl Med, Hangzhou 310003, Peoples R China;[5]Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China

年份：2025

卷号：313

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20243717019428);WOS:【SCI-EXPANDED(收录号:WOS:001313510400001)】；

基金：This work was supported by the National Key Research and Devel-opment Program of China (2021YFA0910000) , National Natural Science Foundation of China (22222803, 22408105) , and the China Post-doctoral Science Foundation (2022M72142) .

语种：英文

外文关键词：Fluorescence; Photoacoustic; Reactive oxygen species (ROS); Atherosclerotic plaque imaging

摘要：Accurate and early detection of atherosclerosis (AS) is imperative for their effective treatment. However, fluorescence probes for efficient diagnosis of AS often encounter insufficient deep tissue penetration, which hinders the reliable assessment of plaque vulnerability. In this work, a reactive oxygen species (ROS) activated near-infrared (NIR) fluorescence and photoacoustic (FL/PA) dual model probe TPA-QO-B is developed by conjugating two chromophores (TPA-QI and O-OH) and ROS-specific group phenylboronic acid ester. The incorporation of ROS-specific group not only induces blue shift in absorbance, but also inhibits the ICT process of TPA-QO-OH, resulting an ignorable initial FL/PA signal. ROS triggers the convertion of TPA-QO-B to TPA-QO-OH, resulting in the concurrent amplification of FL/PA signal. The exceptional selectivity of TPA-QO-B towards ROS makes it effectively distinguish AS mice from the healthy. The NIR emission can achieve a tissue penetration imaging depth of 0.3 cm. Moreover, its PA(775) signal possesses the capability to penetrate tissues up to a thickness of 0.8 cm, ensuring deep in vivo imaging of AS model mice in early stage. The ROS-triggered FL/PA dual signal amplification strategy improves the accuracy and addresses the deep tissue penetration problem simultaneously, providing a promising tool for in vivo tracking biomarkers in life science and preclinical applications.