文献类型：期刊文献

中文题名：2-N,6-O sulfated chitosan evokes periosteal stem cells for bone regeneration

作者：Luli Ji[1,3];Yuanman Yu[1,3];Fuwei Zhu[1,3];Dongao Huang[1,3];Xiaogang Wang[1,3];Jing Wang[1,2];Changsheng Liu[1,3,4]

机构：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai,200237,PR China;[2]The State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,PR China;[3]Engineering Research Center for Biomedical Materials of the Ministry of Education,East China University of Science and Technology,Shanghai,200237,PR China;[4]Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai,200237,PR China

年份：2024

期号：4

起止页码：282

中文期刊名：Bioactive Materials

外文期刊名：生物活性材料（英文）

收录：Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by National Natural Science Foundation of China for Innovative Research Groups(No.51621002);the National Natural Science Foundation of China(No.31870953);supported by the 111 Project(B14018).

语种：英文

中文关键词：2-N;6-O sulfated chitosan;Periosteal stem cells;PDGF-BB;Bone regeneration

摘要：Musculoskeletal injuries and bone defects represent a significant clinical challenge,necessitating innovative approaches for effective bone tissue regeneration.In this study,we investigated the potential of harnessing periosteal stem cells(PSCs)and glycosaminoglycan(GAG)-mimicking materials for in situ bone regeneration.Our findings demonstrated that the introduction of 2-N,6-O sulfated chitosan(26SCS),a GAG-like polysaccharide,enriched PSCs and promoted robust osteogenesis at the defect area.Mechanistically,26SCS amplifies the biological effect of endogenous platelet-derived growth factor-BB(PDGF-BB)through enhancing the interaction between PDGF-BB and its receptor PDGFRβabundantly expressed on PSCs,resulting in strengthened PSC proliferation and osteogenic differentiation.As a result,26SCS effectively improved bone defect repair,even in an osteoporotic mouse model with lowered PDGF-BB level and diminished regenerative potential.Our findings suggested the significant potential of GAG-like biomaterials in regulating PSC behavior,which holds great promise for addressing osteoporotic bone defect repair in future applications.