文献类型：期刊文献

英文题名：Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial

作者：Shang, Ying[1];Zhang, Sheng[1];Gan, Hui-Qi[1];Yan, Kai-Cheng[1,5];Xu, Fugui[2];Mai, Yiyong[2];Chen, Daijie[3];Hu, Xi-Le[1];Zou, Lei[1];James, Tony D.[5,6];He, Xiao-Peng[1,4]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai Key Lab Elect Insulat & Thermal Ageing, 800 Dongchuan RD, Shanghai 200240, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan RD, Shanghai 200240, Peoples R China;[4]Natl Ctr Liver Canc, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China;[5]Univ Bath, Dept Chem, Bath BA2, England;[6]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

年份：2023

卷号：59

期号：8

起止页码：1094

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20230313388851);WOS:【SCI-EXPANDED(收录号:WOS:000910965500001)】；

语种：英文

外文关键词：Graphene - Infrared devices - Nanoribbons - Nanowires - Supramolecular chemistry

摘要：Here, we report the simple construction of a supramolecular glycomaterial for the targeted delivery of antibiotics to P. aeruginosa in a photothermally-controlled manner. A galactose-pyrene conjugate (Gal-pyr) was developed to self-assemble with graphene nanoribbon-based nanowires via pi-pi stacking to produce a supramolecular glycomaterial, which exhibits a 1250-fold enhanced binding avidity toward a galactose-selective lectin when compared to Gal-pyr. The as-prepared glycomaterial when loaded with an antibiotic that acts as an inhibitor of the bacterial folic acid biosynthetic pathway eradicated P. aeruginosa-derived biofilms under near-infrared light irradiation due to the strong photothermal effect of the nanowires accelerating antibiotic release.