文献类型：期刊文献

中文题名：抗氧化药物治疗铅中毒的研究进展

英文题名：Progress in treatment of lead poisoning by antioxidants

作者：黎俊[1,2];黄永平[1];颜崇淮[2]

机构：[1]华东理工大学药学院,上海200237;[2]上海交通大学医学院附属新华医院环境与儿童健康重点实验室,上海200092

年份：2015

卷号：29

期号：2

起止页码：333

中文期刊名：中国药理学与毒理学杂志

外文期刊名：Chinese Journal of Pharmacology and Toxicology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：科技部国家重点基础研究发展计划(2012-CB525001);环境保护部环境保护公益性项目(201309048)~~

语种：中文

中文关键词：铅中毒;抗氧化剂;自由基;螯合剂

外文关键词：lead poisoning;antioxidant;free radicals;chelator

摘要：铅中毒已成为危害我国公共健康的一个较大因素,传统的螯合剂药物副作用较大,且对损伤修复效果甚微,需要发现更理想的药物。抗氧化剂效果明显,副作用较小,且疗效较为持久,因而越来越多的研究关注此类药物的铅中毒治疗作用。本文综述国内外关于铅中毒的抗氧化药物治疗进展,介绍葛根素、槲皮素、姜黄素、大蒜素和褪黑素5种抗氧化药物治疗铅中毒的的实验研究进展,这5种药物能有效降低血铅含量,提高体内抗氧化酶活性并降低氧化应激水平,修复铅对细胞、器官组织的损伤,具有很高的临床应用价值。
Lead poisoning has become a big threat to public health in China. Traditional treatments usually use chelators to accelerate the excretion of lead by forming complex compounds with it. However, chelators exhibit side effects and have little therapeutic effect on lead-induced impairment so that better drugs are needed. As antioxidants are effective for the treatment of lead poisoning, with lasting effect and little side effect, they have been the focus of increasing studies. This review provides a detailed account of updates on the effects of antioxidant drugs in the therapy of lead poisoning, and of the progress in antioxidant activity of puerarin, quercetin, curcumin, allicin and melatonin in treatment of lead poisoning. To some extent, these five types of drugs can reduce lead poisoning by accelerating lead excretion and antioxidant, increase the body′s antioxidant enzyme activity, reduce oxidative stress and repair damage, which promises some clinical value.