文献类型：期刊文献

英文题名：Enantioselective synthesis of spiro-N,O-ketals via iridium and Br?nsted acid co-catalyzed asymmetric formal [4+2] cycloaddition

作者：Xie, Xiang-Qi[1];Li, Xingguang[1];Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2024

卷号：60

期号：11

起止页码：1448

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20240315380778);WOS:【SCI-EXPANDED(收录号:WOS:001141585100001)，CCR-EXPANDED(收录号:WOS:001141585100001)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 22201073, 21925201 and 22161160319) and the Fundamental Research Funds for the Central Universities. We thank the Research Center of Analysis and Test of East China University of Science and Technology for help in the characterization.

语种：英文

外文关键词：Catalysis - Cycloaddition - Enantioselectivity

摘要：We present an iridium and Br & oslash;nsted acid co-catalyzed enantioselective formal [4+2] cycloaddition reaction of cyclic enamides with 2-(1-hydroxyallyl)phenols. This method yields a wide range of N-unsubstituted spiro-N,O-ketals, with good efficiency (up to 94%) and excellent enantioselectivities (most >95% ee). The protocol features easy scale-up and facile product derivatization.