文献类型：期刊文献

中文题名：Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

英文题名：Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

作者：Meng-jiao Dong[1];Shun-li Liu[1];Lin-hua Tan[2,3];岑莲[2,3];付国东[1]

机构：[1]School of Chemistry and Chemical Engineering,Southeast University,Jiangning District,Nanjing 211189,China;[2]Shanghai Key Laboratory of Multiphase Materials Chemical Engineering,Department of Product Engineering,School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China;[3]National Tissue Engineering Center of China,Shanghai 200241,China

年份：2016

卷号：34

期号：5

起止页码：637

中文期刊名：Chinese Journal of Polymer Science

外文期刊名：高分子科学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；

基金：supported by the National Natural Science Foundation of China(Nos.21274020;21074022 and 21304019);the Key Laboratory of Environmental Medicine Engineering of Ministry of Education(Southeast University);National“973”Project Foundation of China(No.2010CB944804);“the Fundamental Research Funds for the Central Universities”

语种：中文

中文关键词：hydrogel metallic implanted subcutaneous implantation compressive azide chemically polymeric glycol

外文关键词：hydrogel metallic implanted subcutaneous implantation compressive azide chemically polymeric glycol

摘要：The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized via the reaction of copper（I）- catalyzed 1,3-dipolar azide-alkyne cycloaddition（CuA AC） with poly（ethylene glycol）-dopamine（PEG-DA）（“Click Chemistry”） followed by complexation with Fe-（3＋） ions to crosslink the polymeric network. The chemical composition and morphology of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy（FTIR）, -1H-NMR and scanning electron microscopy（SEM）. Swelling ratio, mechanical strength, conductivity, and degradation behaviors of the hydrogels were also studied. The effect of the polymer chain length on properties of hydrogels was explored. The compressive strength of hydrogels could reach as high as 13.1 MPa with a conductivity of 2.2 × 10^-5 S·cm^-1. The hydrogels also exhibited excellent thermal stability even at a temperature of 300 °C, whereas degradation of the hydrogel after 7 weeks was observed under a physiological condition. In addition, the hydrogel exhibited a good biocompatibility based on its in vivo performance through an in vivo subcutaneous implantation model. No inflammation and no obvious abnormality of the surrounding tissue were observed when the hydrogel was subcutaneously implanted for 2 weeks. This work is a step towards creating a new pathway to synthesize hydrogels of interpenetrating networks which could be of important applications in the future research.
The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized via the reaction of copper（I）- catalyzed 1,3-dipolar azide-alkyne cycloaddition（CuA AC） with poly（ethylene glycol）-dopamine（PEG-DA）（“Click Chemistry”） followed by complexation with Fe-（3＋） ions to crosslink the polymeric network. The chemical composition and morphology of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy（FTIR）, -1H-NMR and scanning electron microscopy（SEM）. Swelling ratio, mechanical strength, conductivity, and degradation behaviors of the hydrogels were also studied. The effect of the polymer chain length on properties of hydrogels was explored. The compressive strength of hydrogels could reach as high as 13.1 MPa with a conductivity of 2.2 × 10^-5 S·cm^-1. The hydrogels also exhibited excellent thermal stability even at a temperature of 300 °C, whereas degradation of the hydrogel after 7 weeks was observed under a physiological condition. In addition, the hydrogel exhibited a good biocompatibility based on its in vivo performance through an in vivo subcutaneous implantation model. No inflammation and no obvious abnormality of the surrounding tissue were observed when the hydrogel was subcutaneously implanted for 2 weeks. This work is a step towards creating a new pathway to synthesize hydrogels of interpenetrating networks which could be of important applications in the future research.