文献类型：期刊文献

英文题名：Solvent-switchable regioselective 1,2-or 1,6-addition of quinones with boronic acids

作者：Xia, Qi[1];Zhou, Yaxuan[1];Yang, Xiaoning[1];Zhang, Yanqiu[1];Wang, Jiayi[1];Song, Gonghua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2023

卷号：59

期号：54

起止页码：8416

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20232614327402);WOS:【SCI-EXPANDED(收录号:WOS:001010091100001)，CCR-EXPANDED(收录号:WOS:001010091100001)】；

语种：英文

外文关键词：Regioselectivity - Solvents

摘要：An efficient copper-catalyzed solvent-switchable regioselective 1,2- or 1,6-addition of quinones with boronic acids has been developed. This novel catalytic protocol for the synthesis of various quinols and 4-phenoxyphenols was enabled by a simple solvent swap between H2O and MeOH. It features mild reaction conditions, simple and easy operation, broad substrate scope and excellent regioselectivity. The gram-scale reactions as well as the further transformations of both addition products were also successfully investigated.