文献类型：期刊文献

英文题名：Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus

作者：Wang, Zhijie[1];Jiang, Yu[1];Xin, Xiujuan[1];An, Faliang[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：153

外文期刊名：FITOTERAPIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000684861800021)】；

基金：This work was funded by the National Key R&D Program of China (2018YFC1706206, 2019YFC0312504), and the National Natural Science Foundation of China (41876189, 81703388). This work was also supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering and Institute of regulatory science.

语种：英文

外文关键词：Endophytic fungus; Aspergillus lentulus; Indole alkaloids

摘要：As part of our program to discover new bioactive agents from endophytic fungi, three new indole alkaloids (1-2, 4) along with twelve known compounds were isolated from an inset derived endophytic strain Aspergillus lentulus. Their structures were determined by comprehensive spectroscopic analyses of 1D/2D NMR and HR-ESI-MS data. The absolute configurations were confirmed by ECD calculation using Time-dependent Density functional theory (TD-DFT) at the B3LYP/6-31 + g (d, p) level and Rh-2(OCOCF3)(4)-induced ECD experiments. Compounds 2, 4, 5, 13 and 15 exhibited moderate cytotoxic effects on A549 cell line with IC50 in the range of 17.92-48.29 mu M. Compounds 1, 2 and 13-15 displayed the anti-bacterial activity against Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola with MIC values ranging from 25 to 100 mu g/mL.