文献类型：期刊文献

英文题名：Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy

作者：Tang, Qi[1];Zhang, Hai-Lin[1];Wang, Yi[1];Liu, Jing[1];Yang, Shi-Ping[2,3];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[3]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2021

卷号：9

期号：20

起止页码：4241

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20212310447795);WOS:【SCI-EXPANDED(收录号:WOS:000651851000001)】；

基金：This study was financially supported by the National Nature Science Foundation of China (No. 21571062 to JGL), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, and the Fundamental Research Funds for the Central Universities (No. 222201717003).

语种：英文

外文关键词：Diseases - Cancer cells - Mitochondria - Photosensitizers - Titanium dioxide - Carbon monoxide - Manganese compounds - Cell death - Infrared devices - Lanthanum compounds - Biocompatibility - Irradiation - Oxygen

摘要：A multifunctional nanoplatform (1), MnCO@TPP@C-TiO2, which consists of a carrier of carbon-doped TiO2 nanoparticles with surface covalent functionalization of manganese carbonyls and a directing group of triphenylphosphine, was prepared for mitochondria-targeted carbon monoxide (CO) delivery combined with photodynamic therapy (PDT). MnCO@TPP@C-TiO2 selectively localized in the mitochondria of HeLa cells where the overexpressed-H2O2 triggered CO release resulting in mitochondrial damage. And singlet oxygen species generated upon 808 nm near infrared light irradiation further destroyed the mitochondria and induced cancer cells apoptosis. Cytotoxicity assays revealed that the nanoplatform with mitochondria-targeted CO delivery and PDT exhibited the highest lethality against cancer cells in comparison with all the other control samples tested, and it showed good dark biocompatibility with normal cells that express low H2O2 levels. This work may provide new insights into combining CO-based gas therapy with traditional PDT for efficient cancer treatment.