文献类型：期刊文献

英文题名：Interfacial-confined coordination to single-atom nanotherapeutics

作者：Qin, Limei[1];Gan, Jie[2,3];Niu, Dechao[1];Cao, Yueqiang[2,3];Duan, Xuezhi[2,3];Qin, Xing[1];Zhang, Hao[4];Jiang, Zheng[4];Jiang, Yongjun;Dai, Sheng[5,6];Li, Yongsheng[1,7];Shi, Jianlin[8]

机构：[1]East China Univ Sci & Technol, Lab Lowdimens Mat Chem,Shanghai Engn Res Ctr Hier, Key Lab Ultrafine Mat,Sch Mat Sci & Engn, Frontier Sci Ctr Mat Biol & Dynam Chem,Minist Edu, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai, Peoples R China;[5]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[6]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China;[7]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China;[8]Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China

年份：2022

卷号：13

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001028280200003)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002); The National Natural Science Foundation of China (Nos. 52072124 and 51972112); Shanghai Municipal Science and Technology Major Project (grant 2018SHZDZX03); Basic Research Program of Shanghai Municipal Government (Nos. 21JC1406003 and 19JC1411700); Natural Science Foundation of Shanghai (No. 20ZR1414900); Leading talents in Shanghai in 2018; The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; Shanghai Rising-star Program (20QA1402400); The Fundamental Research Funds for the Central Universities (JKVJ1211022) and the 111 project (B14018). We also thank the BL14W1 XAFS beamline of Shanghai Synchrotron Radiation Facility (SSRF) for providing beamtime.

语种：英文

摘要：Pursuing and developing effective methodologies to construct highly active catalytic sites to maximize the atomic and energy efficiency by material engineering are attractive. Relative to the tremendous researches of carbon-based single atom systems, the construction of bioapplicable single atom materials is still in its infancy. Herein, we propose a facile and general interfacial-confined coordination strategy to construct high-quality single-atom nanotherapeutic agent with Fe single atoms being anchored on defective carbon dots confined in a biocompatible mesoporous silica nanoreactor. Furthermore, the efficient energy conversion capability of silica-based Fe single atoms system has been demonstrated on the basis of the exogenous physical photo irradiation and endogenous biochemical reactive oxygen species stimulus in the confined mesoporous network. More importantly, the highest photothermal conversion efficiency with the mechanism of increased electron density and narrow bandgap of this single atom structure in defective carbon was proposed by the theoretical DFT calculations. The present methodology provides a scientific paradigm to design and develop versatile single atom nanotherapeutics with adjustable metal components and tune the corresponding reactions for safe and efficient tumor therapeutic strategy.