文献类型：期刊文献

英文题名：A Molecular Peptide Beacon for the Ratiometric Sensing of Nucleic Acids

作者：Wu, Junchen[2,3,5];Zou, Ying[1];Li, Chunyan[1];Sicking, Wilhelm[5];Piantanida, Ivo[4];Yi, Tao[1];Schmuck, Carsten[5]

机构：[1]Fudan Univ, Dept Chem, Shanghai 200438, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[4]Rudjer Boskovic Inst, HR-10000 Zagreb, Croatia;[5]Univ Duisburg Essen, Inst Organ Chem, D-45117 Essen, Germany

年份：2012

卷号：134

期号：4

起止页码：1958

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20120614742326);WOS:【SCI-EXPANDED(收录号:WOS:000301084600017)】；

基金：J.W. thanks the Alexander von Humboldt Foundation for a postdoctoral fellowship. We thank Christine Kallweit (Institute of Organic Chemistry, University of Duisburg-Essen, Germany) for measuring the CD spectra. T.Y. thanks the National Science Foundation of China (NSFC) for support (30890141 and 21125104).

语种：英文

外文关键词：Peptides

摘要：A pyrene-functionalized cationic oligopeptide 1 efficiently binds to double-stranded DNA, as shown by different spectrophotochemical studies. Upon binding, the conformation of 1 changes from a folded to an extended form, which leads to a distinct change in the fluorescence properties. Thus, 1 functions as a molecular peptide beacon, and as it is easily taken up by cells, 1 can also be used for imaging of nucleic acids within cells.