文献类型：期刊文献

英文题名：Advances in cycloaddition and hydroaddition reaction of α-(trifluoromethyl)styrenes without defluorination: An alternative approach to CF3-containing compounds

作者：Deng, Yupian[1];He, Jingjing[1];Cao, Song[1];Qian, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

年份：2022

卷号：33

期号：5

起止页码：2363

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000789384800014)】；

语种：英文

外文关键词：alpha-(Trifluoromethyl)styrenes; Cycloaddition and hydroaddition; Nondefluorination; CF3-containing compounds

摘要：alpha-(Trifluoromethyl)styrene and its derivatives have found wide applications in the fields of pharmaceuticals, agrochemicals, and advanced materials. They are also versatile trifluoromethyl-containing building blocks for the preparation of various trifluoromethyl-containing, fluorine-containing or nonfluorinated compounds. Recently, great efforts have been made to develop diverse reactions for rapidly accessing a wide range of valuable gem-difluoroalkenes and gem-difluoroalkylated compounds via defluorinative reaction or the defluorinative ipso-functionalization reaction of alpha-(trifluoromethyl)styrenes, respectively. In contrast, alpha-(trifluoromethyl)styrenes remain notably underdeveloped with respect to their use in cycloaddition and hydroaddition reaction with retaining of three C-F bonds. This short review herein is aimed to summarize the recent progress on the cycloaddition and hydroaddition reaction including nucleophilic, radical and transition metal-catalyzed addition of alpha-(trifluoromethyl)styrenes without accompanying defluorination. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.