文献类型：期刊文献

中文题名：超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀

英文题名：Preexpansion of Fine Griseofulvin Particle Formation by Rapid Expansion of Supercritical Solution

作者：陈鸿雁[1];周永传[1];邓修[1];戴干策[1]

机构：[1]华东理工大学化学工程研究所,上海200237

年份：2000

卷号：26

期号：1

起止页码：18

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2000095313535);Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：超临界;灰黄霉素;晶粒细化;溶液体速膨胀

外文关键词：supercriticality; homogeneous nucleation; crystallization; griseofulvinum; grain refinement

摘要：用均相成核理论分析了超临界ＣＯ２ 快速膨胀法（ＲＥＳＳ）制备灰黄霉素微细颗粒过程中的预膨胀操作。指出在类似于灰黄霉素这样在反常冷凝区进行的ＲＥＳＳ过程，预膨胀段的加热不会导致溶质灰黄霉素在预膨胀段提前析出。
The pre expansion operation of rapid expansion of supercritical solution (RESS) is investigated by classical homogeneous nucleation theory in this article. Griseofulvin will not deposit from the supercritical CO 2 even though the supersaturation increases with the increasing pre expansion temperature. Otherwise, the lower pre expansion pressure results in higher nucleation rate. Therefore, high pre expansion temperature can be chosen when higher pre expansion pressure is set.