文献类型：期刊文献

英文题名：One-pot synthesis of α-fluoro-β-amino acid and indole spiro-derivatives via C-N bond cleavage/formation

作者：Tang, Chen-Yu;Wang, Ge;Yang, Xue-Yan;Wu, Xin-Yan[1];Sha, Feng

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：55

期号：47

起止页码：6447

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000344825300015)，CCR-EXPANDED(收录号:WOS:000344825300015)】；

基金：We are grateful for the financial support from National Natural Science Foundation of China (Project Nos. 21102043 and 20122044), the China Postdoctoral Science Foundation (Project Nos. 20110490070 and 2012T50401) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Arynes; Aziridines; Fluorination; beta-Amino acids; Indole spiro-derivatives

摘要：In this Letter, the alpha-fluoro-beta-amino acid directives were elegantly generated via a novel strategy of the nucleophilic addition of arynes and aziridines. C-N bonds were successfully constructed with high efficiency. With the utilization of TABF hydrate as the fluorinated reagent, fluorine atom could be assembled into the target molecule selectively. Interestingly, under another condition, unexpected indole spiro-derivatives could be achieved successfully. (C) 2014 Elsevier Ltd. All rights reserved.