文献类型：期刊文献

中文题名：Photodynamic Therapy of Oligoethylene Glycol-Dendronized Reduction-Sensitive Porphyrins

英文题名：Photodynamic Therapy of Oligoethylene Glycol-Dendronized Reduction-Sensitive Porphyrins

作者：Mingjie Ju;Jundi Pang;Ligong Xu

机构：[1]School of Sports Science and Engineering, East China University of Science and Technology, Shanghai 200237,China;[2]Kunming Medical University, Kunming, Yunnan 650500, China;

年份：2017

卷号：35

期号：9

中文期刊名：中国化学（英文版）

外文期刊名：Chinese Journal of Chemistry

语种：英文

中文关键词：graphene oxide;photodynamic therapy;porphyrindisulfide

外文关键词：graphene oxide;photodynamic therapy;porphyrindisulfide

摘要：Graphene oxide (GO) and its functionalized derivatives have attracted increasing attention in medical treatment.Herein,a reduction sensitive PEI-GO-SS-TPP was synthesized for photodynamic therapy.More than 80％ porphyrin release was observed in the presence of 10 mmol·L-1 DTT in one day.The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI-GO-SS-TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time.For photodynamic therapy,GSH-OEt could effectively increase the photodynamic therapy efficiency of PEI-GO-SS-TPP.Compared with free porphyrin,the toxicity from PEI-GO-SS-TPP is much higher with a low IC50 (2.1 g/mL) value.All results indicate that the PEI-GO-SS-TPP PSs are promising for photodynamic therapy.
Graphene oxide (GO) and its functionalized derivatives have attracted increasing attention in medical treatment.Herein,a reduction sensitive PEI-GO-SS-TPP was synthesized for photodynamic therapy.More than 80％ porphyrin release was observed in the presence of 10 mmol·L-1 DTT in one day.The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI-GO-SS-TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time.For photodynamic therapy,GSH-OEt could effectively increase the photodynamic therapy efficiency of PEI-GO-SS-TPP.Compared with free porphyrin,the toxicity from PEI-GO-SS-TPP is much higher with a low IC50 (2.1 g/mL) value.All results indicate that the PEI-GO-SS-TPP PSs are promising for photodynamic therapy.