文献类型：期刊文献

英文题名：Micro/nano flow chemistry by Beyond Limits Manufacturing

作者：Liu, Peiwen[1];Zhao, Fang[2];Zhang, Jing[2];Bai, Yunpeng[3];Ye, Jinxing[4];Bao, Bo[2];Zhou, Xinggui[2];Zhang, Li[5];Zhou, Changlu[2];Yu, Xinhai[5];Zuo, Peng[3];Xia, Jianye[3];Cen, Lian[2];Yang, Yangyang[1];Shi, Guoyue[6];Xu, Lin[6];Zhu, Weiping[1];Xu, Yufang[1];Qian, Xuhong[1,6]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China;[5]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[6]East China Normal Univ, Sch Chem & Mol Engn, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China

年份：2024

卷号：35

期号：5

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001208945700001)】；

基金：We are grateful to Professor Kai Li for her significant contribution to BLM project management. We appreciate the effort s and contributions of all members from the BLM major project team, as well as the guidance and support of the Shanghai Municipal Development and Reform Commission, Shanghai Municipal Science and Technology Commission , and Shanghai STVC Group.

语种：英文

外文关键词：Beyond Limits Manufacturing; Flow chemistry; Pharmaceutical manufacturing; Microreactor

摘要：In September 2018, we proposed the cutting-edge concept of "Beyond Limits Manufacturing" (BLM). BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser, to invent micro/nano scale flow chips or devices, which makes it possible for the microform, integration, economy, safety, high efficiency, green and intelligence of research, development and manufacturing process, so as to realize transformational manufacturing in the era of Industry 4.0. In this paper, we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project (December 2019 to August 2023), and discussed its application prospects in micro/nano flow chemistry. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.