文献类型：期刊文献

英文题名：Effects of simulated gastric and intestinal digestion on chitooligosaccharides in two in vitro models

作者：Chen, Jiayi[1];Chen, Qiming[1];Xie, Chuanqi[1];Ahmad, Waheed[1];Jiang, Lihua[1];Zhao, Liming[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, R&D Ctr Separat & Extract Technol Fermentat Ind, Shanghai 200237, Peoples R China;[2]SCICBT, Shanghai 200237, Peoples R China

年份：2020

卷号：55

期号：5

起止页码：1881

外文期刊名：INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

收录：;EI(收录号：20193507379106);WOS:【SCI-EXPANDED(收录号:WOS:000484281000001)】；

基金：This work was supported by the National Natural Science Foundation of China (31371725), The National Key Research and Development Program of China (2017YFB0309302) and 'Shu Guang' project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation (15SG28).

语种：英文

外文关键词：Chitooligosaccharides; degree of polymerisation; digestive behaviour; in vitro dynamic digestion model; in vitro static digestion model

摘要：Chitooligosaccharides (COS) with different degree of polymerisation (DP) have different physiological activities such as anti-tumour and anti-hyperlipidemia activities. However, the digestive process might lead to the change of DP of COS as well as cause the change of physiological activities in vivo. In this study, two in vitro digestion models (static and dynamic) were used to investigate digestion behaviours of COS and the influencing factors during digestion with or without food matrix. The results showed that COS with DP 2-5 were indigestible and COS with DP 6-10 degraded with time during gastric and intestinal digestion. Pepsin, pancreatin and lipase were the main factors leading to degradation. Food matrix could protect COS with DP 6-10 from degradation during gastric digestion. However, the degradation of COS with DP 6-10 accelerated and the degradation of COS with DP 5 occurred during intestinal digestion with food matrix due to pancreatin, lipase and bile salt.