文献类型：期刊文献

英文题名：Advancements in life-on-a-chip: The impact of "Beyond Limits Manufacturing" technology

作者：He, Weiwei[1];Zhang, Hongbo[2];Lin, Xudong[3];Zhu, Lili[1];Zheng, Tingting[4];Pei, Hao[4];Tian, Yang[4];Zhang, Min[4];Shi, Guoyue[4];Wu, Lei[5];Zhao, Jianlong[5];Wumaier, Gulinuer[6];Li, Shengqing[6];Xu, Yufang[1];Li, Honglin[1,7,8];Qian, Xuhong[1,4,7]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[3]Sun Yat Sen Univ, Sch Biomed Engn, Guangdong Prov Key Lab Sensor Technol & Biomed Ins, Shenzhen Campus, Shenzhen 518000, Peoples R China;[4]East China Normal Univ, Sch Chem & Mol Engn, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China;[5]Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Shanghai 200050, Peoples R China;[6]Fudan Univ, Huashan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China;[7]East China Normal Univ, Innovat Ctr AI & Drug Discovery, Shanghai 200062, Peoples R China;[8]Lingang Lab, Shanghai 200031, Peoples R China

年份：2024

卷号：35

期号：5

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001209084000001)】；

基金：We thank the "Shanghai Beyond Limits Manufacturing Project " for supporting the realization of the BLM concept for microchip products.

语种：英文

外文关键词：Beyond limit manufacturing; Model-organism-on-a-chip; Organ-on-a-chip

摘要：This review explores the concept of life -on -a -chip, which involves the creation of miniaturized biological systems, such as organs, tissues, and model organisms, on microscale platforms called microfluidic chips. These chips consist of intricately etched channels, wells, and chambers that enable precise control and observation of fluids, cells, and biochemical reactions, facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli, drugs, or disease conditions. The review highlights the application of a novel technology, "Beyond Limit Manufacturing" (BLM), in the development of sophisticated three-dimensional cell models and model organism microchips. Modelorganism -on -a -chip and organ -on -a -chip (OoC) are among the thriving developments in the field of microfluidics, allowing for the reconstruction of living microenvironments and implementation of multiple stimuli. The review discusses the latest advancements in life -on -a -chip technology using BLM and outlines potential future research directions, emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.