文献类型：期刊文献

英文题名：Self-Assembled Multifunctional Supraparticle Films for Label-Free Direct SERS Quantitation of Weakly Adsorbing Molecules in Serum

作者：Zhang, Yingrui[4];Li, Chunchun[3,4];Liu, Weilong[1,2];Huang, Yunpeng[1,2];Ye, Ziwei[1,2];Bell, Steven E. J.[4];Xu, Yikai[1,2];Ma, Xiang[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem, Shanghai 200237, Peoples R China;[4]Queens Univ Belfast, Sch Chem & Chem Engn, Belfast BT7 1NN, North Ireland

年份：2025

卷号：17

期号：44

起止页码：61550

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20254519451775);WOS:【SCI-EXPANDED(收录号:WOS:001599133500001)】；

基金：The authors would like to thank Prof He Tian and Dr Zheng Chen for their support. The authors would like to acknowledge the following funding. The Science and Technology Commission of Shanghai Municipality (Grant No. 24DX1400200). The Natural Science Foundation of China (Grant No. 22402060, 22573031) (Y.X.). The Natural Science Foundation of Shanghai (Grant No. 24ZR1416700) (Y.X.). The Shanghai Pujiang Program (Grant No. 23PJ1409000) (C.L.). The Natural Science Foundation of China (Grant No. 22503032) (C.L.). Natural Science Foundation of China 22503031 (Z.Y.). Chinese Scholarship Council 202008370188 (Y.Z.). The authors acknowledge Vecteezy.com and its authors for providing vector art used in Figure .

语种：英文

外文关键词：SERS; interface self-assembly; pretreatment-free; multifunctional; serum; plasmonics

摘要：Detecting and quantifying molecular species at trace levels is crucial for understanding fundamental processes in chemistry and biology; however, the complexity of real-life samples renders their direct analysis extremely challenging. Here, we demonstrate a surface-enhanced Raman spectroscopic approach for the direct on-site detection and quantification of trace analytes in real-life samples. The key to our approach is the creation of multifunctional plasmonic films via interfacial self-assembly using colloidal Au@Prussian blue (PB) supraparticles as the functional building block. The supraparticles contain 3-dimensional hot-spots that give rise to strong plasmonic near-field enhancement, while the PB shell acts simultaneously as a molecular sieve and internal standard to induce selective analyte adsorption and to calibrate signal fluctuations. This enables direct identification and quantitation of a range of weakly adsorbing targets in biological and environmental samples using a portable Raman spectrometer, which paves the way for rapid on-site chemical analysis in important applications, including therapeutic drug monitoring and environmental analysis.