文献类型：期刊文献

英文题名：Facile synthesis of a well-defined heteroatom-containing main chain polycarbonate for activated intracellular drug release

作者：Sun, Chuanhao[1];Wang, Jiahao[1];Hu, Jieni[1];Lu, Wei[2];Song, Zhongchen[3];Zhang, Yan[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat,Key Lab Ultrafin, Shanghai 200237, Peoples R China;[2]Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 200433, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Periodontol, Sch Med, Shanghai 200011, Peoples R China

年份：2020

卷号：4

期号：8

起止页码：2443

外文期刊名：MATERIALS CHEMISTRY FRONTIERS

收录：;EI(收录号：20203609146469);WOS:【SCI-EXPANDED(收录号:WOS:000557157600020)】；

基金：This work was partially supported by National Natural Science Foundation of China (51873062, 31971264), Shanghai Natural Science Foundation (17ZR1407100), School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, SDD2019-01).

语种：英文

外文关键词：Polycarbonates - Targeted drug delivery - Controlled drug delivery - Amines - Block copolymers - Drug products - Self assembly - Nanoparticles - Polyethylene oxides - Polyethylene glycols

摘要：Multi-responsive drug carriers have great advantages in the targeted delivery of drugs in heterogeneous and complicated biological micro-environments. However, the sophisticated fabrication process is a great obstacle for their further application. Herein, ROS/GSH/pH triple responsive polycarbonate was rationally synthesizedviathe one-pot ring-opening copolymerization of the diselenide and tertiary amine macrocyclic carbonate monomers with methoxy poly(ethylene glycol) as the initiator. The micellar nanoparticles were formed by the amphiphilic block copolymers composed of a PEG segment and diselenide and tertiary amine containing the polycarbonate blockviaself-assembly. The diselenide and tertiary amine groups allowed for rich ROS/GSH/pH responsiveness, which caused these nanoparticles to undergo changes in the size and morphology. These micellar nanoparticles exhibited a stimuli-responsive drug release profile upon the stimulation of acidic pH, GSH, and ROS, and the release mechanism was elucidated. The blank nanoparticles were cyto-compatible, whereas the triple responsive drug-loaded nanoparticles exhibited an improved concentration-dependent and synergistic cytotoxicity towards the A549 cells. More importantly, the micellar nanoparticles could facilitate cell uptake and realize controlled intracellular release. Thus, the newly developed micellar nanocarriers could open a new avenue for smart antitumor drug delivery applications.