文献类型：期刊文献

英文题名：para-Selective, Direct C(sp2)-H Alkylation of Electron-Deficient Arenes by the Electroreduction Process

作者：Ni, Pufan[1,2];Yang, Lei[1,2];Yang, Jiasheng[1,2];Cheng, Ruihua[3];Zhu, Weiping[1,2];Ma, Yueyue[3];Ye, Jinxing[1,2,3]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China

年份：2023

卷号：88

期号：9

起止页码：5248

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20231513882710);WOS:【SCI-EXPANDED(收录号:WOS:000967854100001)，CCR-EXPANDED(收录号:WOS:000967854100001)】；

基金：This work was partially supported by the National Natural Science Foundation of China (22071056 and 22001070) and the Shanghai Sailing Program (20YF1410400) .

语种：英文

外文关键词：Aromatic hydrocarbons - Electrolytic reduction

摘要：Direct para-selective C(sp2)-H alkylation of electron-deficient arenes based on the electroreduction-enabled radical addition of alkyl bromides has been developed under mild conditions. In the absence of any metals and redox agents, the simple electrolysis system tolerates a variety of primary, secondary, and tertiary alkyl bromides and behaves as an important complement to the directed alkylation of the C(sp2)-H bond and the classic Friedel-Crafts alkylation. This electroreduction process provides a more straightforward, environmentally benign, and effective alkylation method for electron-deficient arenes.