文献类型：期刊文献

英文题名：Fine Regulation of Porous Architectures of Core-Shell Silica Nanocomposites Offers Robust Nanoprobes with Accelerated Responsiveness

作者：Shi, Ben[1,2];Gu, Xianfeng[3];Wang, Zhijun[3];Xu, Ge[1,2];Fei, Qiang[1,2];Tang, Jie[1,2];Zhao, Chunchang[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China

年份：2017

卷号：9

期号：41

起止页码：35588

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20174304290057);WOS:【SCI-EXPANDED(收录号:WOS:000413503700009)】；

基金：We gratefully acknowledge the financial support of the National Science Foundation of China (grant numbers 21572039, 21372083, 21672062).

语种：英文

外文关键词：fluorescent probes; silica nanocomposites; fast response; robust; endogenous H2S

摘要：Probes bearing good aqueous solubility and biocompatibility as well as fast response can serve as ideal tools for evaluating the underlying molecular mechanism of endogenous production of H2S caused by drugs; however, they are still lacking but highly desirable. Here, we demonstrate a novel strategy for constructing highly efficient H2S nanoprobes through locking Forster resonance energy transfer borondipyrromethene (BODIPY) pairs in water-dispersible core-shell silica nanoparticles. Importantly, these nanocomposites can effectively confine complementary guests within the same cores due to the existence of a shield, thus guaranteeing efficient Forster resonance energy transfer. Interestingly, the interior microenvironment of such nanoparticles could be tuned by silylation agents. In this way, an ideal probe for rapid and ratiometric detection of H2S within 15 s is established by optimizing the amount of silylation agent with a polar organic group. Obviously, the silylation agents are explored to serve as a platform not only for establishment of robust structures but also for optimizing the microenvironment of the interior to afford an ideal probe. These silica nanocomposites have also been successfully employed in disclosing the endogenous production of H2S induced by estrogen in cardiomyocytes.