文献类型：期刊文献

英文题名：Acetylation of N-heteroaryl bromides via PdCl2/(o-tolyl) 3P catalyzed heck reactions

作者：He, Tianxiong[1]; Tao, Xiaochun[1]; Wu, Xinyan[1]; Cai, Lisheng[2]; Pike, Victor W.[2]

机构：[1] Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237, China; [2] Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States

年份：2008

期号：6

起止页码：887

外文期刊名：Synthesis

收录：EI(收录号：20081411184951)

语种：英文

外文关键词：Acetylation - Alcohols - Bromine compounds - Catalysis - Ethers - Hydrolysis

摘要：A new user-friendly and convenient method for the acetylation of N-heteroaryl bromides is described. This process is based on the palladium-catalyzed olefination of an N-heteroaryl bromide with butyl vinyl ether, followed by acid hydrolysis of the intermediate heteroaryl vinyl ether in situ. Isopropanol at 85°C, in the presence of K3PO 4·3H2O (2 equiv), PdCl2 (2 mol%) and (o-tolyl)3P (4 mol%), provided the best conditions, giving yields of N-heteroaryl bromides up to 75%. ? Georg Thieme Verlag Stuttgart.