文献类型：期刊文献

英文题名：Friction-Adaptive Hydrogel Coating for Mechanical-Immune Synergy in Ligament-to-Bone Integration

作者：Wang, Shuang[1,2]; Chen, Tianwu[4]; Li, Yong[5]; Zhang, Lei[5]; Wang, Jing[1,2]; Liu, Changsheng[2,3]

机构：[1] The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China; [2] Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, China; [3] Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China; [4] Sports Medicine Department, Huashan Hospital, Fudan University, Shanghai, China; [5] State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Yunnan, Kunming, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250394910)

语种：英文

外文关键词：Adhesives - Artificial organs - Coatings - Grafts - Hyaluronic acid - Hydrogen bonds - Ligaments - Plastic bottles

摘要：The long-term success of anterior cruciate ligament (ACL) reconstruction depends on the stable integration between artificial grafts and host bone. Despite their favourable mechanical strength, polyethylene terephthalate (PET) artificial ligaments often suffer from micromotion-induced fibrosis and persistent foreign body reactions (FBR), which together hinder osteointegration. Here, we develop a dual-network hydrogel coating with spatiotemporal immunomodulatory capability, enabling functional "mechano-immune" synergy at the graft-bone interface. Catechol-functionalized hyaluronic acid (HAMA-DOP) forms strong adhesive interactions with PET through π–π stacking, hydrogen bonding, and reversible covalent bonds. Subsequent oxidative crosslinking into a dense quinone-based secondary network enhances shear resistance and fatigue durability, while supporting self-healing. Pluronic F127 diacrylate (PF127-DA) introduces a thermoresponsive structure allowing the hydrogel to transition from injectable fluid at 4 °C to a stable gel at 37 °C, enabling localized and phase-specific release of celecoxib (CXB). This facilitates early suppression of inflammation and sustained promotion of regeneration. In vivo studies reveal a dose-dependent regulatory effect of CXB, where low-dose delivery promotes M2 macrophage polarization, H-type vessel formation, and bone bridging, while high doses impair immune homeostasis and osteointegration. This work establishes a robust, biologically responsive interface strategy, advancing the design of innovative coatings for enhanced clinical outcomes in artificial ligament integration. ? 2025, The Authors. All rights reserved.