文献类型：期刊文献

中文题名：Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations

作者：Zhubo Sheng[1];Jie Deng[1];Qinglong Yuan[1];Wen Fu[1,5];Zhiping Xu[1];Xiaoyan Li[6];Zhong Li[1,2];Xusheng Shao[1,2,3,4]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,China;[3]Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China;[4]Engineering Research Center of Pharmaceutical Process Chemistry,Ministry of Education,School of Pharmacy,East China University of Science and Technology,Shanghai,200237,China;[5]National Key Laboratory of Green Pesticide,Guizhou University,Guiyang,550025,Guizhou,China;[6]College of Humanities and Economic Management,Yantai Institute of China Agricultural University,Yantai,264670,Shandong,China

年份：2026

卷号：5

期号：1

起止页码：33

中文期刊名：Advanced Agrochem

外文期刊名：现代农业化学(英文)

基金：supported by National Natural Science Foundation of China(32472610,32402439,32072441);National Key Research and Development Program of China(2018YFD0200100);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-02-E00037);Tobacco and Health funding program(2022539200340111);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission);the project of National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University(SKL-GPL-KF202405).

语种：英文

中文关键词：TFMP;Carbonyl-bridged;Structure-activity relationships;Molecular docking;Calcium ion

摘要：Trifluoromethyl pyridine(TFMP)motif is commonly discovered in structures of active pharmaceuticals.Flonicamid,characterized by the TFMP moiety,is well known as a prodrug in the knockdown of pests.The azobenzene-modified TFMP derivatives have been previously reported with excellent insecticidal activities.Herein,twenty-one TFMP derivatives were designed by the introduction of carbonyl-bridged aryl groups and synthesized via a one-step synthesis using Flonicamid as the starting material.The structure-activity relationships of these compounds were well analyzed and discussed.A molecular docking study and calcium ion concentration analysis indicated that compound FC13 could have interacted with the nicotinamidase enzyme,which further influenced the Ca^(2+)influx.